Evosep Webinar
Plasma Proteomics in translational medicine
December 11, 2025 – 16:00 CET / 10:00 EST
Unlock the full potential of plasma proteomics with robust LC-MS workflows powered by Evosep. Discover how standardized, Evotip-based methods deliver exceptional depth, reproducibility, and scalability – ideal for large-cohort studies and population-level disease monitoring.
BENCHMARK OF ENRICHMENT AND DEPLETION METHODS FOR QUANTITATIVE PLASMA PROTEOMICS AND THEIR CORRELATION TO CLINICAL ROUTINE MEASUREMENT.
Talk by Anders H. Kverneland, PhD., MD at Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital
In recent years several preparatory techniques for enrichment or depletion for MS proteomics have been developed to overcome the extreme dynamic range in plasma. In this study we test and benchmark several workflows with intra- and inter-sample comparisons. In addition we test the correlaton to clinical routine protein analyte measurements performed at the hospital laboratory.
Pre-analytical drivers of bias in bead-enriched plasma proteomics
Talk by Kathrin Korff, PhD student, Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry
Plasma proteomics holds great promise for biomarker discovery, yet pre-analytical variation, especially contamination from blood cells, can distort protein profiles. We systematically compare five workflows using controlled spike-ins. Bead-based enrichment provides the deepest coverage but shows high sensitivity to platelet and PBMC contamination, risking systematic bias. Our findings highlight a trade-off between depth and robustness and offer guidance for improving data quality in plasma proteomics.
